Dataset Information


Homo sapiens

ABSTRACT: The target genes of EGFR activity in glioma cells

ORGANISM(S): Homo sapiens  



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Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.

Li Ming M   Mukasa Akitake A   Inda Maria del-Mar MM   Zhang Jianhua J   Chin Lynda L   Cavenee Webster W   Furnari Frank F  

The Journal of experimental medicine 20111212 13

Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one of the most frequent genetic lesions in a variety of human tumors. These include glioblastoma multiforme (GBM), which is characterized by independent but interrelated features of extensive invasion into normal brain parenchyma, rapid growth, necrosis, and angiogenesis  ...[more]

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