Dataset Information


Homo sapiens

ABSTRACT: Microarray analysis of gene expression profiles in response to tomato leaves extract treatment in MCF-7 breast cancer cells

ORGANISM(S): Homo sapiens  



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Microarray and quantitative PCR analysis of gene expression profiles in response to treatment with tomato leaf extract in mcf-7 breast cancer cells.

Amid Azura A   Wan Chik Wan Dalila WD   Jamal Parveen P   Hashim Yumi Zuhanis Has-Yun YZ  

Asian Pacific journal of cancer prevention : APJCP 20120101 12

We previously found cytotoxic effects of tomato leaf extract (TLE) on the MCF-7 breast cancer cell line. The aim of this study was to ascertain the molecular mechanisms associated with the usage of TLE as an anticancer agent by microarray analysis using mRNA from MCF-7 breast cancer cells after treatment with TLE for 1 hr and 48 hrs. Approximately 991 genes out of the 30,000 genes in the human genome were significantly (p<0.05) changed after the treatment. Within this gene set, 88 were significa  ...[more]

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