Dataset Information


Xenopus laevis

ABSTRACT: miR-124 acts through coREST to control the onset of Sema3A sensitivity in navigating retinal growth cones

ORGANISM(S): Xenopus laevis  



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miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones.

Baudet Marie-Laure ML   Zivraj Krishna H KH   Abreu-Goodger Cei C   Muldal Alistair A   Armisen Javier J   Blenkiron Cherie C   Goldstein Leonard D LD   Miska Eric A EA   Holt Christine E CE  

Nature neuroscience 20111204 1

During axon pathfinding, growth cones commonly show changes in sensitivity to guidance cues that follow a cell-intrinsic timetable. The cellular timer mechanisms that regulate such changes are, however, poorly understood. Here we have investigated microRNAs (miRNAs) in the timing control of sensitivity to the semaphorin Sema3A in Xenopus laevis retinal ganglion cell (RGC) growth cones. A developmental profiling screen identified miR-124 as a candidate timer. Loss of miR-124 delayed the onset of  ...[more]

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