Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: BW001: E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA148705 | ENA |

REPOSITORIES: ENA

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Publications

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.

Westendorp Bart B   Mokry Michal M   Groot Koerkamp Marian J A MJ   Holstege Frank C P FC   Cuppen Edwin E   de Bruin Alain A  

Nucleic acids research 20111217 8


E2F transcription factors are known to be important for timely activation of G(1)/S and G(2)/M genes required for cell cycle progression, but transcriptional mechanisms for deactivation of cell cycle-regulated genes are unknown. Here, we show that E2F7 is highly expressed during mid to late S-phase, occupies promoters of G(1)/S-regulated genes and represses their transcription. ChIP-seq analysis revealed that E2F7 binds preferentially to genomic sites containing the TTCCCGCC motif, which closely  ...[more]

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