Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Human glioblastoma cells: Tet-on(mutant p53 R175H expression) vs Tet-off(p53-null)

PROVIDER: PRJNA149023 | ENA |

REPOSITORIES: ENA

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Publications

High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.

Imai Hiroo H   Kato Shunsuke S   Sakamoto Yasuhiro Y   Kakudo Yuichi Y   Shimodaira Hideki H   Ishioka Chikashi C  

Oncology reports 20131230 3


The TP53 mutation (R175H) is one of the most common mutations in human cancer. It is a highly attractive strategy for cancer therapy to find the genes that lead the R175H-expressing cancer cells. The aim of this study was to identify the synthetic sick/lethal gene interacting with R175H. Using lentiviral bar-coded comprehensive shRNA library and a tetracycline-inducible R175H expressed in the SF126 human glioblastoma cell line (SF126-tet-R175H), we conducted high-throughput screening to identify  ...[more]

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