Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Nrl-/- Retinal Transcriptomes

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA149389 | ENA |

REPOSITORIES: ENA

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Publications

Next-generation sequencing facilitates quantitative analysis of wild-type and Nrl(-/-) retinal transcriptomes.

Brooks Matthew J MJ   Rajasimha Harsha K HK   Roger Jerome E JE   Swaroop Anand A  

Molecular vision 20111123


Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived retinal transcriptome profiling (RNA-seq) to microarray and quantitative reverse transcription polymerase chain reaction (qRT-PCR) methods and to evaluate protocols for optimal high-throughput data analysis.Retinal mRNA profiles of 21-day-old wild-type (WT) and neural retina leucine zipper knockout (Nrl(-/-)) mice were generated by deep sequencing, i  ...[more]

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