Dataset Information


Mus musculus

ABSTRACT: C2C12 murine myoblast cell line and 48 h 10 uM BIO treated C2C12 cellulate

ORGANISM(S): Mus musculus  



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Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency.

Kim Woong-Hee WH   Jung Da-Woon DW   Kim Jinmi J   Im Sin-Hyeog SH   Hwang Seung Yong SY   Williams Darren R DR  

ACS chemical biology 20120209 4

In urodele amphibians, an early step in limb regeneration is skeletal muscle fiber dedifferentiation into a cellulate that proliferates to contribute new limb tissue. However, mammalian muscle cannot dedifferentiate after injury. We have developed a novel, small-molecule-based method to induce dedifferentiation in mammalian skeletal muscle. Muscle cellularization was induced by the small molecule myoseverin. Candidate small molecules were tested for the induction of proliferation in the cellulat  ...[more]

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