Genomics

Dataset Information

20

Homo sapiens


ABSTRACT: Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFbeta signaling pathways

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA150737 | ENA |

REPOSITORIES: ENA

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Publications

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways.

Coulouarn Cédric C   Cavard Catherine C   Rubbia-Brandt Laura L   Audebourg Anne A   Dumont Florent F   Jacques Sébastien S   Just Pierre-Alexandre PA   Clément Bruno B   Gilgenkrantz Hélène H   Perret Christine C   Terris Benoît B  

Carcinogenesis 20120613 9


Intrahepatic malignant tumours include hepatocellular carcinomas (HCC), cholangiocarcinomas (CC) and combined hepatocholangiocarcinomas (cHCC-CC), a group of rare and poorly characterized tumours that exhibit both biliary and hepatocytic differentiation. The aim of the study was to characterize the molecular pathways specifically associated with cHCC-CC pathogenesis. We performed a genome-wide transcriptional analysis of 20 histologically defined cHCC-CC and compared them with a series of typica  ...[more]

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