Genomics

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ABSTRACT: Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma

PROVIDER: PRJNA150743 | ENA |

REPOSITORIES: ENA

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Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.

Matsumura Satoshi S   Imoto Issei I   Kozaki Ken-ichi K   Matsui Takeshi T   Muramatsu Tomoki T   Furuta Mayuko M   Tanaka Shinji S   Sakamoto Michiie M   Arii Shigeki S   Inazawa Johji J  

Clinical cancer research : an official journal of the American Association for Cancer Research 20120509 13


PURPOSE: The aim of this study was the identification of novel tumor suppressor genes (TSG) silenced by DNA hypermethylation in hepatocellular carcinoma (HCC). EXPERIMENTAL DESIGN: We conducted integrative array-based approach for genome-wide screening of methylation targets using a methylated DNA immunoprecipitation-CpG island microarray and expression array in three universal hepatoma cell lines and normal liver tissue. Through detailed expression and functional analyses using hepatoma cell li  ...[more]

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