Dataset Information


Homo sapiens

ABSTRACT: Expression data from Control and Six1 expressing MCF7 derived xenograft tumors

ORGANISM(S): Homo sapiens  



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SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer.

Wang Chu-An CA   Jedlicka Paul P   Patrick Aaron N AN   Micalizzi Douglas S DS   Lemmer Kimberly C KC   Deitsch Erin E   Casás-Selves Matias M   Harrell J Chuck JC   Ford Heide L HL  

The Journal of clinical investigation 20120402 5

An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells infiltrate the lymphatic system are not completely understood. Recently, it has been proposed that the lymphatic system has an active role in metastatic dissemination and that tumor-secreted growth factors stimulate lymphangiogenesis. We therefore investigated whether SIX1, a homeodomain-containing transcription factor previously associated in br  ...[more]

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