Dataset Information


Mus musculus

ABSTRACT: p38a-dependent gene expression in dendritic cells

ORGANISM(S): Mus musculus  



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Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease.

Ritprajak Patcharee P   Hayakawa Morisada M   Sano Yasuyo Y   Otsu Kinya K   Park Jin Mo JM  

Proceedings of the National Academy of Sciences of the United States of America 20120521 23

The kinase p38α, originally identified because of its endotoxin- and cytokine-inducible activity and affinity for antiinflammatory compounds, has been posited as a promising therapeutic target for various immune-mediated disorders. In clinical trials, however, p38α inhibitors produced adverse skin reactions and other toxic effects that often outweighed their benefits. Such toxicity may arise from a perturbation of physiological functions unrelated to or even protective against the disease being  ...[more]

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