Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA150755 | ENA |

REPOSITORIES: ENA

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Publications


MHC I-associated peptides (MIPs) play an essential role in normal homeostasis and diverse pathologic conditions. MIPs derive mainly from defective ribosomal products (DRiPs), a subset of nascent proteins that fail to achieve a proper conformation and the physical nature of which remains elusive. In the present study, we used high-throughput proteomic and transcriptomic methods to unravel the structure and biogenesis of MIPs presented by HLA-A and HLA-B molecules on human EBV-infected B lymphocyt  ...[more]

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