Dataset Information


Mus musculus

ABSTRACT: Polysome-bound mRNA during oocyte maturation

ORGANISM(S): Mus musculus  



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Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.

Chen Jing J   Melton Collin C   Suh Nayoung N   Oh Jeong Su JS   Horner Kathleen K   Xie Fang F   Sette Claudio C   Blelloch Robert R   Conti Marco M  

Genes & development 20110401 7

Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional events that are driving these transitions. Here we used a systems approach by combining polysome mRNA profiling and bioinformatics to identify RNA-binding motifs in mRNAs that either enter or exit the polysome pool during mouse oocyte maturation. Association of mRNA with the polysomes correlates with activ  ...[more]

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