Dataset Information


Homo sapiens

ABSTRACT: Genome-Wide Mapping Of Time-Series ChIP-Seq Data For Human ERα Breast Cancer Cell Line (MCF-7)

ORGANISM(S): Homo sapiens  



altmetric image


Hierarchical modularity in ERα transcriptional network is associated with distinct functions and implicates clinical outcomes.

Tang Binhua B   Hsu Hang-Kai HK   Hsu Pei-Yin PY   Bonneville Russell R   Chen Su-Shing SS   Huang Tim H-M TH   Jin Victor X VX  

Scientific reports 20121119

Recent genome-wide profiling reveals highly complex regulation networks among ERα and its targets. We integrated estrogen (E2)-stimulated time-series ERα ChIP-seq and gene expression data to identify the ERα-centered transcription factor (TF) hubs and their target genes, and inferred the time-variant hierarchical network structures using a Bayesian multivariate modeling approach. With its recurrent motif patterns, we determined three embedded regulatory modules from the ERα core transcriptional  ...[more]

Similar Datasets

2016-10-25 | E-GEOD-78284 | ArrayExpress
| GSE74033 | GEO
2016-10-25 | E-GEOD-78285 | ArrayExpress
2013-05-08 | E-GEOD-43835 | ArrayExpress
2019-03-21 | PXD012930 | Pride
| GSE74032 | GEO
2015-03-04 | E-GEOD-62789 | ArrayExpress
| GSE73320 | GEO
2018-10-22 | E-MTAB-5537 | ArrayExpress
2011-06-03 | E-GEOD-23852 | ArrayExpress