Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiling of PC3 cells stably expressing ERbeta1 and ERbeta2

ORGANISM(S): Homo sapiens  



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Estrogen receptors β1 and β2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3.

Dey Prasenjit P   Jonsson Philip P   Hartman Johan J   Williams Cecilia C   Ström Anders A   Gustafsson Jan-Åke JÅ  

Molecular endocrinology (Baltimore, Md.) 20121001 12

The estrogen receptor (ER)β1 is successively lost during cancer progression, whereas its splice variant, ERβ2, is expressed in advanced prostate cancer. The latter form of cancer often metastasizes to bone, and we wanted to investigate whether the loss of ERβ1 and/or the expression of ERβ2 affect such signaling pathways in prostate cancer. Using PC3 and 22Rv1 prostate cancer cell lines that stably express ERβ1 or ERβ2, we found that the ERβ variants differentially regulate genes known to affect  ...[more]

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