Genomics

Dataset Information

118

Mus musculus


ABSTRACT: MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA150921 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.

Creppe Catherine C   Janich Peggy P   Cantariño Neus N   Noguera Marc M   Valero Vanesa V   Musulén Eva E   Douet Julien J   Posavec Melanija M   Martín-Caballero Juan J   Sumoy Lauro L   Di Croce Luciano L   Benitah Salvador A SA   Buschbeck Marcus M  

Molecular and cellular biology 20120213 8


One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into the poorly recognized function of macroH2A in transcriptional activation and demonstrate its relevance in embryonic and adult stem cells. Knockdown of macroH2A1 in mouse embryonic stem (mES) cells limited their capacity to differentiate but not their self-renewal. The loss of macroH2A1 interfered  ...[more]

Similar Datasets

2012-02-20 | E-GEOD-35087 | ArrayExpress
| PRJNA132061 | ENA
2008-12-05 | BIOMD0000000209 | BioModels
2008-12-05 | BIOMD0000000210 | BioModels
| GSE73426 | GEO
| PRJNA429482 | ENA
2017-10-18 | PXD003281 | Pride
2013-12-01 | E-GEOD-45486 | ArrayExpress
2008-11-25 | BIOMD0000000203 | BioModels
2008-11-26 | BIOMD0000000204 | BioModels