Dataset Information


Mus musculus

ABSTRACT: Role of the hypoxia-inducible histone H3K9 methylation regulating enzymes Jmjd1a and G9a in stem cell self-renewal and tumorigenesis

ORGANISM(S): Mus musculus  



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The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

Ueda Jun J   Ho Jolene Caifeng JC   Lee Kian Leong KL   Kitajima Shojiro S   Yang Henry H   Sun Wendi W   Fukuhara Noriko N   Zaiden Norazean N   Chan Shing Leng SL   Tachibana Makoto M   Shinkai Yoichi Y   Kato Hiroyuki H   Poellinger Lorenz L  

Molecular and cellular biology 20140728 19

Hypoxia promotes stem cell maintenance and tumor progression, but it remains unclear how it regulates long-term adaptation toward these processes. We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-derived tumors, such as seminomas, yolk sac tumors, and embryonal carcinomas. Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor in opposition to the hypox  ...[more]

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