Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Role of the hypoxia-inducible histone H3K9 methylation regulating enzymes Jmjd1a and G9a in stem cell self-renewal and tumorigenesis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA150935 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.

Ueda Jun J   Ho Jolene Caifeng JC   Lee Kian Leong KL   Kitajima Shojiro S   Yang Henry H   Sun Wendi W   Fukuhara Noriko N   Zaiden Norazean N   Chan Shing Leng SL   Tachibana Makoto M   Shinkai Yoichi Y   Kato Hiroyuki H   Poellinger Lorenz L  

Molecular and cellular biology 20140728 19


Hypoxia promotes stem cell maintenance and tumor progression, but it remains unclear how it regulates long-term adaptation toward these processes. We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-derived tumors, such as seminomas, yolk sac tumors, and embryonal carcinomas. Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor in opposition to the hypox  ...[more]

Similar Datasets

| GSE35061 | GEO
2014-07-30 | E-GEOD-35061 | ArrayExpress
| GSE98761 | GEO
| GSE89891 | GEO
| GSE66894 | GEO
| GSE103022 | GEO
2013-08-03 | E-GEOD-49513 | ArrayExpress
| GSE94085 | GEO
| GSE94033 | GEO
2015-01-20 | E-GEOD-54412 | ArrayExpress