Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Expression data from mouse kidney tissue

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA151539 | ENA |

REPOSITORIES: ENA

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Publications


The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT(1) antagonism ameliorate renal damage. However, it is unclear which mechanism exerts better nephroprotection. We compared the renin inhibitor aliskiren with the AT(1) antagonist losartan in mice with chronic kidney disease due to renal ablation. Doses were adjusted to equipotent inhibition of the renin-angiotensin s  ...[more]

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