Genomics

Dataset Information

25

Mus musculus


ABSTRACT: Gene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA151801 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


A therapeutic strategy for treating cancer is to target and eradicate cancer stem cells (CSCs) without harming their normal stem cell counterparts. The success of this approach relies on the identification of molecular pathways that selectively regulate CSC function. Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for CSCs, we show that BCR-ABL downregulates the Blk gene (encoding B-lymphoid kinase) through c-Myc in leukemic stem cells (LSCs) in CML mice and that Blk func  ...[more]

Similar Datasets

| PRJNA156155 | ENA
| PRJNA138603 | ENA
2012-04-03 | E-GEOD-35183 | ArrayExpress
2012-04-03 | E-GEOD-35111 | ArrayExpress
2012-04-04 | GSE35111 | GEO
2011-05-17 | E-GEOD-29347 | ArrayExpress
2011-05-17 | GSE29347 | GEO
2012-07-05 | E-GEOD-36096 | ArrayExpress
| PRJNA107207 | ENA
2016-07-07 | E-GEOD-81842 | ArrayExpress