Genomics

Dataset Information

0

Oryzias latipes


ABSTRACT: Regulation of cholesterogenic gene expression in Japanese medaka (Oryzias latipes) exposed to 17β-trenbolone

ORGANISM(S): Oryzias latipes  

PROVIDER: PRJNA152009 | ENA |

REPOSITORIES: ENA

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Publications

17β-Trenbolone exposure programs metabolic dysfunction in larval medaka.

Mizukami-Murata Satomi S   Kishi-Kadota Katsuyuki K   Nishida Takashi T  

Environmental toxicology 20150604 11


Here, we used physiological and transcriptomic analyses to evaluate the effects of 17β-trenbolone (TB) on metabolism during the early life stage of medaka (Oryzias latipes). In the physiological experiments, sex reversal rates increased continuously in proportion to TB concentrations (2-100 ng/L), and were 100% (all males) in the 200 ng/L treatment group. TB caused a significant increase in the gonadosomatic index of females at concentrations of 60 and 100 ng/L. These females exhibited swollen a  ...[more]

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