Genomics

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ABSTRACT: Gene expression variation in horse placental and fetal tissue, and resting and stimulated horse lymphocytes

PROVIDER: PRJNA152203 | ENA |

REPOSITORIES: ENA

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IL-22 is expressed by the invasive trophoblast of the equine (Equus caballus) chorionic girdle.

Brosnahan Margaret M MM   Miller Donald C DC   Adams Mackenzie M   Antczak Douglas F DF  

Journal of immunology (Baltimore, Md. : 1950) 20120404 9


The invasive trophoblast cells of the equine placenta migrate into the endometrium to form endometrial cups, dense accumulations of trophoblast cells that produce equine chorionic gonadotropin between days 40 and 120 of normal pregnancy. The mechanisms by which the trophoblast cells invade the endometrium while evading maternal immune destruction are poorly defined. A gene expression microarray analysis performed on placental tissues obtained at day 34 of gestation revealed a >900-fold upregulat  ...[more]

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