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Omics score: 1000

Mus musculus

ABSTRACT: Microarray analysis on livers, spleens and hearts of mice given distilled water fed with either a normal diet or an atherogenic diet

PROVIDER: PRJNA154575 | ENA |

REPOSITORIES: ENA

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Publications

Oil palm phenolics attenuate changes caused by an atherogenic diet in mice.

Leow Soon-Sen SS Sekaran Shamala Devi SD Sundram Kalyana K Tan YewAi Y Sambanthamurthi Ravigadevi R

European journal of nutrition 20120411 2

<h4>Background</h4>Water-soluble phenolics from the oil palm possess significant biological properties.<h4>Purpose</h4>In this study, we aimed to discover the role of oil palm phenolics (OPP) in influencing the gene expression changes caused by an atherogenic diet in mice.<h4>Methods</h4>We fed mice with either a low-fat normal diet (14.6 % kcal/kcal fat) with distilled water, or a high-fat atherogenic diet (40.5 % kcal/kcal fat) containing cholesterol. The latter group was given either distille ...[more]

PMID: 22527284

Similar Datasets

Atherogenic diet supplemented with oil palm phenolics effect on liver, spleen, and heart

Project description:This SuperSeries is composed of the following subset Series: GSE30905: Microarray analysis on livers, spleens and hearts of mice given distilled water fed with either a normal diet or an atherogenic diet GSE30907: Microarray analysis on livers, spleens and hearts of mice fed an atherogenic diet and supplemented with either oil palm phenolics (OPP) or distilled water Refer to individual Series

| E-GEOD-30908 | BioStudies

Atherogenic diet supplemented with oil palm phenolics effect on liver, spleen, and heart

2011-07-25 | E-GEOD-30908 | ArrayExpress

Microarray analysis on livers, spleens and hearts of mice given distilled water fed with either a normal diet or an atherogenic diet

Project description:BALB/c mice were given an atherogenic diet and compared to those given a normal diet to observe for gene expression changes caused by the atherogenic diet. Both groups of mice received distilled water as drinks ad libitum. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that the atherogenic diet caused oxidative stress and inflammation in the organs. Total RNA obtained from livers, spleens and hearts of BALB/c mice given an atherogenic diet (six weeks after the feeding regimen) was compared to those from organs of mice given normal diet (liver: four replicates in the treatment group versus four replicates in the control group; spleen and heart: three replicates in the treatment group versus four replicates in the control group for both organs)

| E-GEOD-30905 | BioStudies

Microarray analysis on livers, spleens and hearts of mice fed an atherogenic diet and supplemented with either oil palm phenolics (OPP) or distilled water

Project description:OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice given an atherogenic diet for six weeks to observe for possible anti-atherogenic effects. The control group received distilled water instead of OPP. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that OPP attenuated the effects of the atherogenic diet in the organs. Total RNA obtained from livers, spleens and hearts of BALB/c mice given OPP (six weeks after administration of an atherogenic diet) were compared to controls given distilled water (liver: three replicates in the treatment group versus four replicates in the control group; spleen and heart: three replicates in the treatment group versus three replicates in the control group for both organs)

| E-GEOD-30907 | BioStudies

Oil palm phenolics attenuate changes caused by an atherogenic diet in mice.

Project description:<h4>Background</h4>Water-soluble phenolics from the oil palm possess significant biological properties.<h4>Purpose</h4>In this study, we aimed to discover the role of oil palm phenolics (OPP) in influencing the gene expression changes caused by an atherogenic diet in mice.<h4>Methods</h4>We fed mice with either a low-fat normal diet (14.6 % kcal/kcal fat) with distilled water, or a high-fat atherogenic diet (40.5 % kcal/kcal fat) containing cholesterol. The latter group was given either distilled water or OPP. We harvested major organs such as livers, spleens and hearts for microarray gene expression profiling analysis. We determined how OPP changed the gene expression profiles caused by the atherogenic diet. In addition to gene expression studies, we carried out physiological observations, blood hematology as well as clinical biochemistry, cytokine profiling and antioxidant assays on their blood sera.<h4>Results</h4>Using Illumina microarrays, we found that the atherogenic diet caused oxidative stress, inflammation and increased turnover of metabolites and cells in the liver, spleen and heart. In contrast, OPP showed signs of attenuating these effects. The extract increased unfolded protein response in the liver, attenuated antigen presentation and processing in the spleen and up-regulated antioxidant genes in the heart. Real-time quantitative reverse transcription-polymerase chain reaction validated the microarray gene expression fold changes observed. Serum cytokine profiling showed that OPP attenuated inflammation by modulating the Th1/Th2 axis toward the latter. OPP also increased serum antioxidant activity to normal levels.<h4>Conclusion</h4>This study suggests that OPP may possibly attenuate atherosclerosis and other forms of cardiovascular disease.

| S-EPMC3573186 | BioStudies

Microarray analysis on livers, spleens and hearts of mice given distilled water fed with either a normal diet or an atherogenic diet

Project description:BALB/c mice were given an atherogenic diet and compared to those given a normal diet to observe for gene expression changes caused by the atherogenic diet. Both groups of mice received distilled water as drinks ad libitum. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that the atherogenic diet caused oxidative stress and inflammation in the organs. Overall design: Total RNA obtained from livers, spleens and hearts of BALB/c mice given an atherogenic diet (six weeks after the feeding regimen) was compared to those from organs of mice given normal diet (liver: four replicates in the treatment group versus four replicates in the control group; spleen and heart: three replicates in the treatment group versus four replicates in the control group for both organs)

2011-07-26 | GSE30905 | GEO

Microarray analysis on livers, spleens and hearts of mice given distilled water fed with either a normal diet or an atherogenic diet

2011-07-25 | E-GEOD-30905 | ArrayExpress

Microarray analysis on livers, spleens and hearts of mice fed an atherogenic diet and supplemented with either oil palm phenolics (OPP) or distilled water

2011-07-25 | E-GEOD-30907 | ArrayExpress

Microarray analysis on livers, spleens and hearts of mice fed a normal diet and supplemented with either oil palm phenolics (OPP) or distilled water

Project description:OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice given a normal diet to observe for possible biological activities. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that OPP may have pleiotropic biological properties in vivo. Total RNA obtained from livers, spleens and hearts of BALB/c mice given OPP (six weeks after the feeding regimen) were compared to controls given distilled water (liver: three replicates in the treatment group versus four replicates in the control group; spleen and heart: four replicates in the treatment group versus four replicates in the control group for both organs)

| E-GEOD-28824 | BioStudies

Microarray analysis on livers, spleens and hearts of mice fed a normal diet and supplemented with either oil palm phenolics (OPP) or distilled water

Project description:OPP (1500 ppm gallic acid equivalent (GAE)) was supplemented to BALB/c mice given a normal diet to observe for possible biological activities. Livers, spleens and hearts were harvested six weeks after the feeding regimen for gene expression studies. Results from the separate microarray data analysis carried out on the different organs show that OPP may have pleiotropic biological properties in vivo. Overall design: Total RNA obtained from livers, spleens and hearts of BALB/c mice given OPP (six weeks after the feeding regimen) were compared to controls given distilled water (liver: three replicates in the treatment group versus four replicates in the control group; spleen and heart: four replicates in the treatment group versus four replicates in the control group for both organs)

2011-04-26 | GSE28824 | GEO

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