Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: RRBS (Reduced Representation Bisulfite Sequencing) of HL60

PROVIDER: PRJNA154871 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR358709.fastq.gz Fastqsanger.gz
SRR358710.fastq.gz Fastqsanger.gz
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Publications


DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile. This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. Deep sequencing of transcripts associated with DNMT1 combined with gen  ...[more]

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