Dataset Information


Homo sapiens

ABSTRACT: Expression data from transfection of U87 glioma cells with miR-376a* for 72 hours

ORGANISM(S): Homo sapiens  



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Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells.

Choudhury Yukti Y   Tay Felix Chang FC   Lam Dang Hoang DH   Sandanaraj Edwin E   Tang Carol C   Ang Beng-Ti BT   Wang Shu S  

The Journal of clinical investigation 20121024 11

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster undergo programmed "seed" sequence modifications by adenosine-to-inosine (A-to-I) editing. Emerging evidence suggests a link between impaired A-to-I editing and cancer, particularly in high-grade gliomas. We hypothesized that disruption of A-to-I editing alters expression of genes regulating glioma tumor phenotypes. By sequencing the miR-376 cluster, we show that the overall miRNA editing frequencies were reduced in h  ...[more]

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