Dataset Information


Homo sapiens

ABSTRACT: FOXO3 regulates gene expression from distal enhancers

ORGANISM(S): Homo sapiens  



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Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.

Eijkelenboom Astrid A   Mokry Michal M   de Wit Elzo E   Smits Lydia M LM   Polderman Paulien E PE   van Triest Miranda H MH   van Boxtel Ruben R   Schulze Almut A   de Laat Wouter W   Cuppen Edwin E   Burgering Boudewijn M T BM  

Molecular systems biology 20130101

Forkhead box O (FOXO) transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into the mechanisms of FOXO-regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes shows that FOXO3 regulates gene expression through transcription initiation. Correlative analysis of FOXO3 and RNA polymerase II ChIP-seq profiles demonstrates FOXO3 to act as a trans  ...[more]

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