Dataset Information


Homo sapiens

ABSTRACT: Goldengate Methylation analysis: Ewing Sarcoma

ORGANISM(S): Homo sapiens  



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DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.

Patel Nikul N   Black Jennifer J   Chen Xi X   Marcondes A Mario AM   Grady William M WM   Lawlor Elizabeth R ER   Borinstein Scott C SC  

Sarcoma 20120912

The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded EWS tumors and 3 EWS cell lines was compared to human mesenchymal stem cell primary cultures (hMSCs) using bead chip methylation analysis. Relative expression of methylated genes was assessed in 5-Aza-2-deoxycytidine-(5-AZA)-treated EWS cell lines and in a cohort of primary EWS samples and hMSCs by gene expression and quantitative RT-PCR.  ...[more]

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