Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Goldengate Methylation analysis: Ewing Sarcoma

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA156959 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

DNA methylation and gene expression profiling of ewing sarcoma primary tumors reveal genes that are potential targets of epigenetic inactivation.

Patel Nikul N   Black Jennifer J   Chen Xi X   Marcondes A Mario AM   Grady William M WM   Lawlor Elizabeth R ER   Borinstein Scott C SC  

Sarcoma 20120912


The role of aberrant DNA methylation in Ewing sarcoma is not completely understood. The methylation status of 503 genes in 52 formalin-fixed paraffin-embedded EWS tumors and 3 EWS cell lines was compared to human mesenchymal stem cell primary cultures (hMSCs) using bead chip methylation analysis. Relative expression of methylated genes was assessed in 5-Aza-2-deoxycytidine-(5-AZA)-treated EWS cell lines and in a cohort of primary EWS samples and hMSCs by gene expression and quantitative RT-PCR.  ...[more]

Similar Datasets

2012-09-01 | E-GEOD-36859 | ArrayExpress
| GSE89041 | GEO
| GSE88826 | GEO
2018-12-04 | GSE109477 | GEO
2015-07-11 | E-GEOD-44934 | ExpressionAtlas
2010-04-01 | E-GEOD-15696 | ArrayExpress
2011-08-25 | GSE23936 | GEO
| GSE89026 | GEO
2011-08-24 | E-GEOD-23936 | ArrayExpress
2010-04-01 | GSE15696 | GEO