Genomics

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ABSTRACT: Clonal competition with alternating dominance in multiple myeloma

PROVIDER: PRJNA156981 | ENA |

REPOSITORIES: ENA

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The longitudinal evolution of a myeloma genome from diagnosis to plasma cell leukemia has not previously been reported. We used whole-genome sequencing (WGS) on 4 purified tumor samples and patient germline DNA drawn over a 5-year period in a t(4;14) multiple myeloma patient. Tumor samples were acquired at diagnosis, first relapse, second relapse, and end-stage secondary plasma cell leukemia (sPCL). In addition to the t(4;14), all tumor time points also shared 10 common single-nucleotide variant  ...[more]

Publication: 1/2

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