Dataset Information


Mus musculus

ABSTRACT: Gene Expression profiling in DBA/2J glaucoma

ORGANISM(S): Mus musculus  



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Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.

Howell Gareth R GR   Soto Ileana I   Zhu Xianjun X   Ryan Margaret M   Macalinao Danilo G DG   Sousa Gregory L GL   Caddle Lura B LB   MacNicoll Katharine H KH   Barbay Jessica M JM   Porciatti Vittorio V   Anderson Michael G MG   Smith Richard S RS   Clark Abbot F AF   Libby Richard T RT   John Simon W M SW  

The Journal of clinical investigation 20120319 4

Glaucoma is a common ocular disorder that is a leading cause of blindness worldwide. It is characterized by the dysfunction and loss of retinal ganglion cells (RGCs). Although many studies have implicated various molecules in glaucoma, no mechanism has been shown to be responsible for the earliest detectable damage to RGCs and their axons in the optic nerve. Here, we show that the leukocyte transendothelial migration pathway is activated in the optic nerve head at the earliest stages of disease  ...[more]

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