Dataset Information


Mus musculus

ABSTRACT: Expression profiling of aging liver in low-fat diet mice

ORGANISM(S): Mus musculus  



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Midlife gene expressions identify modulators of aging through dietary interventions.

Zhou Bing B   Yang Liu L   Li Shoufeng S   Huang Jialiang J   Chen Haiyang H   Hou Lei L   Wang Jinbo J   Green Christopher D CD   Yan Zhen Z   Huang Xun X   Kaeberlein Matt M   Zhu Li L   Xiao Huasheng H   Liu Yong Y   Han Jing-Dong J JD  

Proceedings of the National Academy of Sciences of the United States of America 20120416 19

Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes. Intriguingly, mitochondrial gene expressio  ...[more]

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