Dataset Information


Canis lupus familiaris

ABSTRACT: Acid Stress Increases Gene Expression of Proinflammatory Cytokines in Madin Darby Canine Kidney Cells

ORGANISM(S): Canis lupus familiaris  



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Acid stress increases gene expression of proinflammatory cytokines in Madin-Darby canine kidney cells.

Raj Suraja S   Scott David R DR   Nguyen Thomas T   Sachs George G   Kraut Jeffrey A JA  

American journal of physiology. Renal physiology 20121017 1

Metabolic acidosis is thought to exacerbate chronic kidney disease in part by stimulating the release of potentially injurious substances. To define the genes whose expression is affected by exposure to an acidic milieus, we examined the effect of exposure of MDCK cells to pH 7.4 and pH 7.0 for 24 h on gene expression using a canine derived microarray. Exposure to this pH stress for 24 h led to increased expression of 278 genes (2.2% of the transcriptome) by at least 2-fold and 60 of these (21%)  ...[more]

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