Dataset Information


Homo sapiens

ABSTRACT: The Epstein-Barr virus induced tumor suppressor miR-34a is growth promoting in EBV-infected B cells

ORGANISM(S): Homo sapiens  



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The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells.

Forte Eleonora E   Salinas Raul E RE   Chang Christina C   Zhou Ting T   Linnstaedt Sarah D SD   Gottwein Eva E   Jacobs Cassandra C   Jima Dereje D   Li Qi-Jing QJ   Dave Sandeep S SS   Luftig Micah A MA  

Journal of virology 20120411 12

Epstein-Barr virus (EBV) infection of primary human B cells drives their indefinite proliferation into lymphoblastoid cell lines (LCLs). B cell immortalization depends on expression of viral latency genes, as well as the regulation of host genes. Given the important role of microRNAs (miRNAs) in regulating fundamental cellular processes, in this study, we assayed changes in host miRNA expression during primary B cell infection by EBV. We observed and validated dynamic changes in several miRNAs f  ...[more]

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