Dataset Information


Homo sapiens

ABSTRACT: Expression data from fibroblast-like synoviocytes (FLS) transfected with mimic-miR-23b or mimic-NC

ORGANISM(S): Homo sapiens  



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The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.

Zhu Shu S   Pan Wen W   Song Xinyang X   Liu Yan Y   Shao Xinrui X   Tang Yuanjia Y   Liang Dong D   He Dongyi D   Wang Honglin H   Liu Wenjun W   Shi Yufang Y   Harley John B JB   Shen Nan N   Qian Youcun Y  

Nature medicine 20120701 7

Inflammatory cytokines such as interleukin-17 (IL-17) promote inflammatory autoimmune diseases. Although several microRNAs (miRNAs) have been shown to regulate autoimmune pathogenesis by affecting lymphocyte development and function, the role of miRNAs in resident cells present in inflammatory lesions remains unclear. Here we show that miR-23b is downregulated in inflammatory lesions of humans with lupus or rheumatoid arthritis, as well as in the mouse models of lupus, rheumatoid arthritis or mu  ...[more]

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