Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Staphylococcus hominis subsp. hominis ZBW5

ABSTRACT: Staphylococcus hominis subsp. hominis ZBW5 Genome sequencing and assembly

PROVIDER: PRJNA163345 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The ubiquitous human skin commensal Staphylococcus hominis protects against opportunistic pathogens

Project description:Staphylococcus hominis is frequently isolated from human skin and we hypothesize that it may protect the cutaneous barrier from opportunistic pathogens. We determined that S. hominis makes six unique auto inducing peptide (AIP) signals that inhibit the major virulence factor accessory gene regulator (agr) quorum sensing system of Staphylococcus aureus. We solved and confirmed the structures of three novel AIP signals in conditioned media by mass spectrometry, then validated synthetic AIP activity against all S. aureus agr classes. Synthetic AIPs also inhibited the conserved agr system in a related species, Staphylococcus epidermidis. We determined the distribution of S. hominis agr types on healthy human skin and found S. hominis agr-I and agr-II were highly represented across subjects. Further, synthetic AIP-II was protective in vivo against S. aureus-associated dermonecrotic or epicutaneous injury. Together, these findings demonstrate that a ubiquitous colonizer of human skin has a fundamentally protective role against opportunistic damage.

2022-04-04 | GSE199818 | GEO

Staphylococcus hominis subsp. hominis strain:WiKim0113

Project description:Genomic analysis of Staphylococcus hominis subsp. hominis Wikim0113

| PRJNA750864 | ENA

Staphylococcus hominis

Project description:Staphylococcus hominis Genome sequencing and assembly

| PRJNA545381 | ENA

Staphylococcus hominis subsp. novobiosepticus strain:MBF12-19J

Project description:Staphylococcus hominis subsp. novobiosepticus strain:MBF12-19J Genome sequencing and assembly

| PRJNA720100 | ENA

Staphylococcus hominis VCU122

Project description:Staphylococcus hominis VCU122 Genome sequencing and assembly