Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Mouse ooplasm confers context-specific reprogramming capacity

PROVIDER: PRJNA168490 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR513220.fastq.gz Fastqsanger.gz
SRR513221.fastq.gz Fastqsanger.gz
SRR513222.fastq.gz Fastqsanger.gz
SRR513223.fastq.gz Fastqsanger.gz
SRR513224.fastq.gz Fastqsanger.gz
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Publications

Mouse ooplasm confers context-specific reprogramming capacity.

Chan Michelle M MM   Smith Zachary D ZD   Egli Dieter D   Regev Aviv A   Meissner Alexander A  

Nature genetics 20120819 9


Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. ...[more]

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