Dataset Information


Mus musculus

ABSTRACT: Gene expression profiling of mouse uterine tissue from progesterone receptor-Cre knockout of Dicer

ORGANISM(S): Mus musculus  



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Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer.

Hawkins Shannon M SM   Andreu-Vieyra Claudia V CV   Kim Tae Hoon TH   Jeong Jae-Wook JW   Hodgson Myles C MC   Chen Ruihong R   Creighton Chad J CJ   Lydon John P JP   Gunaratne Preethi H PH   DeMayo Francesco J FJ   Matzuk Martin M MM  

Molecular endocrinology (Baltimore, Md.) 20120713 9

Epithelial-stromal interactions in the uterus are required for normal uterine functions such as pregnancy, and multiple signaling pathways are essential for this process. Although Dicer and microRNA (miRNA) have been implicated in several reproductive processes, the specific roles of Dicer and miRNA in uterine development are not known. To address the roles of miRNA in the regulation of key uterine pathways, we generated a conditional knockout of Dicer in the postnatal uterine epithelium and str  ...[more]

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