Genomics

Dataset Information

59

Homo sapiens


ABSTRACT: Effect of TET1 and TET3 overexpression on the transcriptome of HEK293 cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA170177 | ENA |

REPOSITORIES: ENA

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Publications

Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells.

Grosser Christian C   Wagner Nicholas N   Grothaus Katrin K   Horsthemke Bernhard B  

Epigenetics 20150717 9


The TET family of dioxygenases (TET1/2/3) can convert 5-methylcytosine (5 mC) into 5-hydroxymethylcytosine (5 hmC) and has been shown to be involved in active and passive DNA demethylation. Here, we demonstrate that altering TET dioxygenase levels within physiological range can affect DNA methylation dynamics of HEK293 cells. Overexpression of TET1 increased global 5 hmC levels and was accompanied by mild DNA demethylation of promoters, gene bodies and CpG islands. Conversely, the simultaneous k  ...[more]

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