Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: GEP data from BCWM.1 cells treated with LNA antimiR-155 or scramble control

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA170178 | ENA |

REPOSITORIES: ENA

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Publications


miR-155 acts as an oncogenic miR in B-cell lymphoproliferative disorders, including Waldenstrom macroglobulinemia (WM) and chronic lymphocytic leukemia, and is therefore a potential target for therapeutic intervention. However, efficient targeting of miRs in tumor cells in vivo remains a significant challenge for the development of miR-155-based therapeutics for the treatment of B-cell malignancies. In the present study, we show that an 8-mer locked nucleic acid anti-miR-155 oligonucleotide targ  ...[more]

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