Dataset Information


Homo sapiens

ABSTRACT: Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

ORGANISM(S): Homo sapiens  



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Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.

Roller Devin G DG   Axelrod Mark M   Capaldo Brian J BJ   Jensen Karin K   Mackey Aaron A   Weber Michael J MJ   Gioeli Daniel D  

Molecular cancer therapeutics 20120907 11

Recent data show that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways, suggesting that the inhibition of a single component of a canonical pathway is insufficient for the treatment of cancer. The biologic outcome of signaling through a network is inherently more robust and resistant to inhibition of a single network component. In this study, we conducted a functional chemical genetic screen to identify novel interactions between sig  ...[more]

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