Dataset Information


Homo sapiens

ABSTRACT: Gene Expression of ESC and iPSC lines after specific differentiation

ORGANISM(S): Homo sapiens  



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Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells.

Ruiz Sergio S   Diep Dinh D   Gore Athurva A   Panopoulos Athanasia D AD   Montserrat Nuria N   Plongthongkum Nongluk N   Kumar Sachin S   Fung Ho-Lim HL   Giorgetti Alessandra A   Bilic Josipa J   Batchelder Erika M EM   Zaehres Holm H   Kan Natalia G NG   Schöler Hans Robert HR   Mercola Mark M   Zhang Kun K   Izpisua Belmonte Juan Carlos JC  

Proceedings of the National Academy of Sciences of the United States of America 20120918 40

Generation of human induced pluripotent stem cells (hiPSCs) by the expression of specific transcription factors depends on successful epigenetic reprogramming to a pluripotent state. Although hiPSCs and human embryonic stem cells (hESCs) display a similar epigenome, recent reports demonstrated the persistence of specific epigenetic marks from the somatic cell type of origin and aberrant methylation patterns in hiPSCs. However, it remains unknown whether the use of different somatic cell sources,  ...[more]

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