Dataset Information


Rattus norvegicus

ABSTRACT: Hepatic transcriptome of rats treated with vehicle or fipronil (3 mg/kg/d per os for 14 days)



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The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.

Roques Béatrice B BB   Leghait Julien J   Lacroix Marlène Z MZ   Lasserre Frédéric F   Pineau Thierry T   Viguié Catherine C   Martin Pascal G P PG  

Biochemical pharmacology 20130817 7

Fipronil is described as a thyroid disruptor in rat. Based on the hypothesis that this results from a perturbation of hepatic thyroid hormone metabolism, our goal was to investigate the pathways involved in fipronil-induced liver gene expression regulations. First, we performed a microarray screening in the liver of rats treated with fipronil or vehicle. Fipronil treatment led to the upregulation of several genes involved in the metabolism of xenobiotics, including the cytochrome P450 Cyp2b1, Cy  ...[more]

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