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Arabidopsis thaliana

ABSTRACT: Transcriptome analysis of ire1 mutants after treatment with or without tunicamycin in the presence of actinomycin D

OTHER RELATED OMICS DATASETS IN: E-GEOD-39690

PROVIDER: PRJNA171484 | ENA |

REPOSITORIES: ENA

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E-GEOD-39690

Project description:Transcriptome analysis of ire1 mutants after treatment with or without tunicamycin in the presence of actinomycin D

2016-01-08 | E-GEOD-39690 | ExpressionAtlas

Expression analysis of Candida glabrata CBS138 delta-cnb1, delta-crz1, delta-slt2, and delta-ire1 mutants in response to tunicamycin exposure (Transcriptional response of Candida glabrata to tunicamycin exposure)

2013-05-31 | GSE29855 | GEO

Project description:Investigation of whole genome gene expression level changes in response to tunicamycin, an inhibitor of protein N-glycosylation, in Candida glabrata CBS138 delta-cnb1, delta-crz1, delta-slt2, and delta-ire1 mutants, compared to the wild-type strain. The mutations engineered into these strains render them hypersusceptible to tunicamycin. The mutants analyzed in this study are further described in Miyazaki, T. et al. (2010) Antimicrob Agents Chemother. 54(4):1639-1643 (PMID: 20100876) and Miyazaki, T. et al. (2010) FEMS Yeast Res 10(3):343-352, 2010 (PMID: 20214686). A fifteen chip study using total RNA isolated from Candida glabrata wild-type control and four mutant strains, in which the entire ORFs of CNB1 (XP_448800), CRZ1 (XP_449644), SLT2 (XP_447735), or IRE1 (XP_446111) are deleted. Each chip measures the expression level of 5,217 genes from Candida glabrata CBS138 with six 60-mer-probe pairs per gene, with two-fold technical redundancy.

2013-05-31 | E-GEOD-29855 | biostudies-arrayexpress

Arabidopsis thaliana

Project description:flg22 treatment & mutants-Gene profiling upon biotic stress treatment. Gene profiling in microRNA mutants.

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Arabidopsis thaliana

Project description:flg22 treatment & mutants 2-Gene profiling upon biotic stress treatment. Gene profiling in microRNA mutants.

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Arabidopsis thaliana

Project description:agrobacterium treatment-Gene profiling upon biotic stress treatment. Gene profiling in microRNA mutants.

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Arabidopsis thaliana

Project description:comparisons wt-mutants 2 -Gene profiling upon biotic stress treatment. Gene profiling in microRNA mutants.

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Arabidopsis thaliana

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Transcriptome profile of Dictyostelium cell during ER-stress

Project description:The Unfolded Protein Response (UPR) is an adaptive pathway that restores cellular homeostasis after endoplasmic reticulum (ER) stress caused by an impairment of its protein folding capacity. The ER-resident kinase/ribonuclease Ire1 is the only UPR sensor that has been conserved during evolution from yeast to mammals; in these organisms, Ire1 transmits information from the ER to the nucleus trough the non-conventional splicing of Hac1 (yeast)/Xbp1 (metazoans) mRNA. We described the Dictyostelium discoideum ER-stress response and characterized its single bonafide Ire1 orthologue, IreA. We found that tunicamycin (TN) triggers a gene-expression program that increases the protein folding capacity of the ER and that alleviates ER protein load. Further, IreA resulted essential not only for cell-survival after TN-induced ER-stress, but also to accomplish about nearly 40% of the transcriptional changes induced upon a TN treatment. In addition, we described that autophagy is activated in Dictyostelium cells after a TN treatment and that autophagy-defective mutants exhibited increased sensitivity to this drug. The response of Dictyostelium cells to ER-stress involves the combined activation of an IreA-dependent gene expression program and the autophagy pathway.

2018-04-28 | GSE104409 | GEO

Transcriptome analysis of ire1 mutants after treatment with or without tunicamycin in the presence of actinomycin D

Project description:Arabidopsis seedlings of wildtype or ire1a ire1b double mutant were treated with or without tunicamycine in the presence of actinomycin D (ActD).

2013-03-19 | GSE39690 | GEO

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