Genomics

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ABSTRACT: Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses

PROVIDER: PRJNA172167 | ENA |

REPOSITORIES: ENA

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Distinct signal transduction pathways downstream of the (P)RR revealed by microarray and ChIP-chip analyses.

Zaade Daniela D   Schmitz Jennifer J   Benke Eileen E   Klare Sabrina S   Seidel Kerstin K   Kirsch Sebastian S   Goldin-Lang Petra P   Zollmann Frank S FS   Unger Thomas T   Funke-Kaiser Heiko H  

PloS one 20130304 3


The (pro)renin receptor ((P)RR) signaling is involved in different pathophysiologies ranging from cardiorenal end-organ damage via diabetic retinopathy to tumorigenesis. We have previously shown that the transcription factor promyelocytic leukemia zinc finger (PLZF) is an adaptor protein of the (P)RR. Furthermore, recent publications suggest that major functions of the (P)RR are mediated ligand-independently by its transmembrane and intracellular part, which acts as an accessory protein of V-ATP  ...[more]

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