Dataset Information


Klebsiella pneumoniae subsp. pneumoniae MGH 78578

ABSTRACT: Expression analysis of Klebsiella pneumoniae MGH 78578 and capsule deletion mutant

ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae MGH 78578  



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Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578.

Huang Tzu-Wen TW   Lam Irene I   Chang Hwan-You HY   Tsai Shih-Feng SF   Palsson Bernhard O BO   Charusanti Pep P  

BMC research notes 20140108

BACKGROUND: Klebsiella pneumoniae is a leading cause of hospital-acquired urinary tract infections and pneumonia worldwide, and is responsible for many cases of pyogenic liver abscess among diabetic patients in Asia. A defining characteristic of this pathogen is the presence of a thick, exterior capsule that has been reported to play a role in biofilm formation and to protect the organism from threats such antibiotics and host immune challenge. FINDINGS: We constructed two knockout mutants of K.  ...[more]

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