Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA173417 | ENA |

REPOSITORIES: ENA

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Publications


The Mediator complex functions as a control center, orchestrating diverse signaling, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that directs differentiation into smooth muscle cells (SMCs) or adipocytes. Med23 deficiency facilitates SMC differentiation but represses adipocyte differentiation from the multipotent mesenchymal stem cells. G  ...[more]

Publication: 1/2

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