Other,Multiomics

Dataset Information

1K

Mycobacterium tuberculosis


ABSTRACT: High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis (RNA-seq)

OTHER RELATED OMICS DATASETS IN: GSE40862E-GEOD-40845E-GEOD-40846

PROVIDER: PRJNA175135 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR568038.fastq.gz Fastqsanger.gz
SRR568039.fastq.gz Fastqsanger.gz
SRR568040.fastq.gz Fastqsanger.gz
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Publications

High-resolution transcriptome and genome-wide dynamics of RNA polymerase and NusA in Mycobacterium tuberculosis.

Uplekar Swapna S   Rougemont Jacques J   Cole Stewart T ST   Sala Claudia C  

Nucleic acids research 20121207 2


To construct a regulatory map of the genome of the human pathogen, Mycobacterium tuberculosis, we applied two complementary high-resolution approaches: strand-specific RNA-seq, to survey the global transcriptome, and ChIP-seq, to monitor the genome-wide dynamics of RNA polymerase (RNAP) and the anti-terminator NusA. Although NusA does not bind directly to DNA, but rather to RNAP and/or to the nascent transcript, we demonstrate that NusA interacts with RNAP ubiquitously throughout the chromosome,  ...[more]

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