Dataset Information


Mus musculus

ABSTRACT: Sox2 ablation in the DP alters its gene expression signature

ORGANISM(S): Mus musculus  



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Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.

Clavel Carlos C   Grisanti Laura L   Zemla Roland R   Rezza Amelie A   Barros Rita R   Sennett Rachel R   Mazloom Amin Reza AR   Chung Chi-Yeh CY   Cai Xiaoqiang X   Cai Chen-Leng CL   Pevny Larysa L   Nicolis Silvia S   Ma'ayan Avi A   Rendl Michael M  

Developmental cell 20121101 5

How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18(Cre) to target embryonic DP precursors, we ablate the transcription factor Sox2 early and efficiently, resulting in diminished hair shaft outgrowth. We find that DP niche expression of Sox2 controls the migration speed of differentiating hair shaft progenitors. Transcriptional profiling of Sox2 null DPs reveals increased Bmp6 and decreased BMP inhibitor Sostdc1, a direct Sox  ...[more]

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