Dataset Information


Mus musculus

ABSTRACT: Cebpa regulates gene transcription in basophils

ORGANISM(S): Mus musculus  



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Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates.

Qi Xiaopeng X   Hong Jessie J   Chaves Lee L   Zhuang Yonghua Y   Chen Yuhong Y   Wang Demin D   Chabon Jacob J   Graham Brian B   Ohmori Keitaro K   Li Yapeng Y   Huang Hua H  

Immunity 20130718 1

It remains unclear whether basophils and mast cells are derived from a common progenitor. Furthermore, how basophil versus mast cell fate is specified has not been investigated. Here, we have identified a population of granulocyte-macrophage progenitors (GMPs) that were highly enriched in the capacity to differentiate into basophils and mast cells while retaining a limited capacity to differentiate into myeloid cells. We have designated these progenitor cells "pre-basophil and mast cell progenit  ...[more]

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