Dataset Information


Homo sapiens

ABSTRACT: Attenuation of Global Transcript Changes Induced by Elastase with Symplostatin 5 Cotreatment

ORGANISM(S): Homo sapiens  



altmetric image


Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.

Salvador Lilibeth A LA   Taori Kanchan K   Biggs Jason S JS   Jakoncic Jean J   Ostrov David A DA   Paul Valerie J VJ   Luesch Hendrik H  

Journal of medicinal chemistry 20130128 3

We discovered new structural diversity to a prevalent, yet medicinally underappreciated, cyanobacterial protease inhibitor scaffold and undertook comprehensive protease profiling to reveal potent and selective elastase inhibition. Structure-activity relationship (SAR) studies and X-ray cocrystal structure analysis allowed a detailed assessment of critical and tunable structural elements. To realize the therapeutic potential of these cyclodepsipeptides, we probed the cellular effects of a novel a  ...[more]

Similar Datasets

2013-01-28 | E-GEOD-41600 | ArrayExpress
2012-06-02 | GSE38396 | GEO
2012-06-01 | E-GEOD-38396 | ArrayExpress
| GSE20463 | GEO
2011-02-19 | E-GEOD-20463 | ArrayExpress
2011-08-25 | GSE23936 | GEO
2011-08-24 | E-GEOD-23936 | ArrayExpress
2010-09-25 | GSE24338 | GEO
2014-08-06 | E-GEOD-58734 | ArrayExpress
2010-09-25 | E-GEOD-24338 | ArrayExpress