Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Id1 knockdown in primary human glioma stem cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA177719 | ENA |

REPOSITORIES: ENA

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Publications


Inhibitor of differentiation 1 (ID1) is highly expressed in glioblastoma stem cells (GSCs). However, the regulatory mechanism responsible for its role in GSCs is poorly understood. Here, we report that ID1 activates GSC proliferation, self-renewal, and tumorigenicity by suppressing CULLIN3 ubiquitin ligase. ID1 induces cell proliferation through increase of CYCLIN E, a target molecule of CULLIN3. ID1 overexpression or CULLIN3 knockdown confers GSC features and tumorigenicity to murine Ink4a/Arf-  ...[more]

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