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Toxicogenomics and phenotypic characterization of adult female and zebrafish liver treated with cadmium (II)

ABSTRACT: Toxicogenomics and phenotypic characterization of adult female and zebrafish liver treated with cadmium (II)

PROVIDER: PRJNA177725 | ENA |

REPOSITORIES: ENA

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Toxicogenomics and phenotypic characterization of adult female zebrafish liver treated with cadmium (II)

Project description:We performed microarray-based expression profiling on liver of female zebrafish exposed to 30 µg/L of cadmium (II) chloride for 8-96 h, to identify global transcriptional programs and biological pathways involved in cadmium-induced adaptive responses under in vivo environment.

2013-12-31 | GSE41622 | GEO

Toxicogenomics and phenotypic characterization of adult female zebrafish liver treated with cadmium (II)

Project description:We performed microarray-based expression profiling on liver of female zebrafish exposed to 30 Âµg/L of cadmium (II) chloride for 8-96 h, to identify global transcriptional programs and biological pathways involved in cadmium-induced adaptive responses under in vivo environment. We analyzed 10 arrays of Cadmium-treated adult female zebrafish liver and 12 arrays of control fish.

2013-12-31 | E-GEOD-41622 | biostudies-arrayexpress

Toxicogenomics and phenotypic characterization of adult male zebrafish liver treated with cadmium (II)

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 30 Âµg/L of cadmium (II) chloride for 8-96 h, to identify global transcriptional programs and biological pathways involved in cadmium-induced adaptive responses under in vivo environment. We analyzed 10 arrays of Cadmium-treated adult male zebrafish liver and 12 arrays of control fish.

2013-12-31 | E-GEOD-41623 | biostudies-arrayexpress

Toxicogenomics and phenotypic characterization of adult male zebrafish liver treated with cadmium (II)

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 30 µg/L of cadmium (II) chloride for 8-96 h, to identify global transcriptional programs and biological pathways involved in cadmium-induced adaptive responses under in vivo environment.

2013-12-31 | GSE41623 | GEO

Toxicogenomics and phenotypic characterization of adult female and zebrafish liver treated with cadmium (II)

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-12-31 | GSE41625 | GEO

Toxicogenomics and phenotypic characterization of adult female and zebrafish liver treated with cadmium (II)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-31 | E-GEOD-41625 | biostudies-arrayexpress

Toxicogenomics and phenotypic characterization of adult female zebrafish liver treated with nitrophenol

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 7 mg/L of nitrophenol for 8-96 h, to identify global transcriptional programs and biological pathways involved in chloroaniline-induced adaptive responses under in vivo environment.

2013-06-01 | GSE30060 | GEO

Toxicogenomics and phenotypic characterization of adult female zebrafish liver treated with chloroaniline

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 30 µg/L of chloroaniline for 8-96 h, to identify global transcriptional programs and biological pathways involved in chloroaniline-induced adaptive responses under in vivo environment.

2013-06-01 | GSE30057 | GEO

Bioaccumulation, cellular and molecular effects in adult zebrafish after exposure to cadmium sulphide quantum dots and ionic cadmium

Project description:Few works have addressed the effects provoked by the exposure to cadmium containing nanoparticles (NPs) on adult zebrafish (Danio rerio). We studied the effects of CdS NPs (5 nm) or ionic cadmium (10 µg Cd/L) after 3 and 21 d of exposure and at 6 months post-exposure (mpe). Acute toxicity was recorded after exposure to both forms of cadmium. Significant cadmium accumulation was measured in the whole fish after both treatments and autometallography showed a higher accumulation of metal in the intestine than that in the liver. Histopathological alterations, such as inflammation in gills and vacuolization in the liver, were detected after the exposure to both cadmium forms and, in a lower extent, at 6 mpe. X-ray analysis proved the presence of CdS NPs in these organs. The hepatic transcriptome analysis revealed that gene ontology terms such as “immune response” or “actin binding” were over-represented after 21 d of exposure to ionic cadmium respect to CdS NPs treatment. Exposure to CdS NPs caused a significant effect on pathways involved in the immune response and oxidative stress, while the exposure to ionic cadmium affected significantly pathways involved in DNA damage and repair and in the energetic metabolism. Oxidative damage to liver proteins was detected after the exposure to ionic cadmium, while a stronger destabilization of the hepatocyte lysosomal membrane was recorded under exposure to CdS NPs. In summary, although ionic cadmium provoked stronger effects than CdS NPs, both cadmium forms exerted an array of lethal and sublethal effects to zebrafish.

2019-05-31 | GSE89756 | GEO

Toxicogenomics and phenotypic characterization of adult female zebrafish liver treated with chloroaniline

Project description:We performed microarray-based expression profiling on liver of male zebrafish exposed to 30 Âµg/L of chloroaniline for 8-96 h, to identify global transcriptional programs and biological pathways involved in chloroaniline-induced adaptive responses under in vivo environment. We analyzed 12 arrays of chloroaniline-treated adult female zebrafish liver and 12 arrays of control fish.

2013-06-01 | E-GEOD-30057 | biostudies-arrayexpress

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